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Eleanor STRIDE (University of Oxford, United Kingdom)

Characterisation of Microbubble Dynamics for Ultrasound Mediated Drug Delivery

Title: Characterisation of Microbubble Dynamics for Ultrasound Mediated Drug Delivery
Author: Eleanor Stride
Affiliation: Professor of Engineering Science, Institute of Biomedical Engineering, University of Oxford, United Kingdom
Email: eleanor.stride[at]eng.ox.ac.uk
URL: http://www.ibme.ox.ac.uk/research/non-invasive-therapy-drug-delivery/people/dr-eleanor-stride
Abstract: Gas microbubbles stabilised by a surfactant or polymer coating have been in use as contrast agents for ultrasound imaging for several decades. They are also rapidly becoming established as agents for targeted drug delivery and other therapeutic applications, for example in the treatment of stroke. High-speed imaging, for example using streak and rotating mirror cameras has provided extraordinary insights into the behaviour of these microbubbles, including their interactions with biological structures. In this talk the use of a range of different high speed imaging techniques for characterising microbubble behaviour will be discussed. In particular: understanding the physics of microbubble formation to improve manufacturing processes; investigating the influence of different coating compositions and the microbubble environment on their response to ultrasound excitation; and characterising the flow field around the microbubble that has been shown to play a key role in drug delivery. Finally a high throughput system for microbubble characterisation will be presented.
Biographical Sketch: Eleanor Stride obtained her BEng and PhD in Mechanical Engineering from University College London, where she subsequently appointed to a lectureship and a Royal Academy of Engineering and Engineering and Physical Sciences Research Council (EPSRC) Research Fellowship. In 2011 she was awarded an EPSRC Challenging Engineering grant and joined the Biomedical Ultrasonics, Biotherapy and Biopharmaceutical Laboratory (BUBBL) in the Oxford Institute of Biomedical Engineering, where she became a Professor in 2014. Her research is focused in two complementary areas:
(1) Drug delivery systems engineering
-Advanced encapsulation methods for the fabrication of drug carriers
-Controlled release and biophysics of therapeutic delivery -Theranostics and treatment monitoring 
(2) Biomedical ultrasonics
-Engineering microbubble agents for diagnostic and therapeutic applications
-Physics of cavitation in high intensity focused ultrasound
-Biophysical effects of ultrasound
High speed imaging plays a key role in her research both in understanding the physics underpinning the formation of drug encapsulating structures and their subsequent release and interaction with tissue. She has published over 125 refereed journal papers, 4 book chapters and presented over 100 conference papers. Her work has been recognized through the award of a Philip Leverhulme prize, The EPSRC & Journal of the Royal Society Interface Award, the Engineering Medal at the Parliamentary Science, Engineering & Technology for Britain awards, the Bruce Lindsay Award from the Acoustical Society of America and the IET A F Harvey prize.

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